Traditional Chinese Medicine (TCM) has a 3000 years’ history of human use. A literature survey addressing traditional evidence from human studies was done, with key result that top 10 TCM herb ingredients including Poria cocos, Radix polygalae, Radix glycyrrhizae, Radix angelica sinensis, and Radix rehmanniae were prioritized for highest potential benefit to dementia intervention, related to the highest frequency of use in 236 formulae collected from 29 ancient Pharmacopoeias, ancient formula books, or historical archives on ancient renowned TCM doctors, over the past 10 centuries. Based on the history of use, there was strong clinical support that Radix polygalae is memory improving. Pharmacological investigation also indicated that all the five ingredients mentioned above can elicit memory-improving effects in vivo and in vitro via multiple mechanisms of action, covering estrogenlike, cholinergic, antioxidant, anti-inflammatory, antiapoptotic, neurogenetic, and anti-Aβ activities. Furthermore, 11 active principles were identified, including sinapic acid, tenuifolin, isoliquiritigenin, liquiritigenin, glabridin, ferulic acid, Z-ligustilide, N-methyl-beta-carboline-3-carboxamide, coniferyl ferulate and 11-angeloylsenkyunolide F, and catalpol. It can be concluded that TCM has a potential for complementary and alternative role in treating senile dementia. The scientific evidence is being continuously mined to back up the traditional medical wisdom.
Once upon a time in ancient China, there was a peaceful village nestled between rolling hills and a flowing river. The villagers lived harmoniously, practicing the ancient art of Chinese medicine to maintain their health and well-being. In this village, five extraordinary friends set out on a journey that would teach them the power of the five elements in Chinese medicine. The five friends were named Fire, Earth, Metal, Water, and Wood. Each of them possessed unique qualities and talents, making them inseparable companions. Fire was a lively and passionate friend, full of energy and warmth. Earth was nurturing and caring, always providing a stable and supportive presence. Metal was strong and precise, embodying clarity and determination. Water was fluid and adaptable, representing wisdom and the ability to flow with life's changes. Wood was adventurous and ambitious, representing growth and renewal. One day, they heard of a wise healer living high atop a distant mountain, known f...
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